Emendating

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Concurrent use with drugs that induce the CYP3A4 enzyme system including rifampin, carbamazepine, and phenytoin may ↓ blood levels and effects of aprepitant.↑ blood levels and effects of dexamethasone (regimen reflects a 50% dose reduction); a similar effect occurs with methylprednisolone (↓ IV dose by 25%, ↓ PO dose by 50% when used concurrently).

Concurrent use with drugs that significantly inhibit the CYP3A4 enzyme system including (ketoconazole, itraconazole, nefazodone, clarithromycin, ritonavir, nelfinavir, and diltiazem ) may ↑ blood levels and effects of aprepitant.

agli atti unilaterali a contenuto patrimoniale, in quanto compatibile - di fornire la prova della rilevanza dell’errore, con riguardo ai requisiti della sua essenzialità ed obiettiva riconoscibilità da parte dell’amministrazione finanziaria. 3286 del 19 febbraio 2016 (udienza 14 aprile 2015) Cassazione civile, sezione V - Pres.

Adults: Single-dose regimen: 150 mg (fosaprepitant dimeglumine) by I. infusion over 20 to 30 minutes starting 30 minutes before chemotherapy, with 12 mg dexamethasone P.

CNS: dizziness, neuropathy, headache, insomnia, asthenia, fatigue EENT: tinnitus GI: nausea, vomiting, constipation, diarrhea, epigastric discomfort, gastritis, heartburn, abdominal pain, anorexia Hematologic: neutropenia Other: fever, dehydration, hiccups Drug-drug.

Don't mix with other solutions, including lactated Ringer's and Hartmann's solutions.

Concurrent use with other medications that are metabolized by CYP3A4 may result in ↑ toxicity from these agents including docetaxel, paclitaxel, etoposide, irinotecan, ifosfamide, imatinib, vinorelbine, vinblastine, vincristine, midazolam, triazolam, and alprazolam ; concurrent use should be undertaken with caution.

To prevent nausea and vomiting caused by moderately emetogenic cancer chemotherapy Adults: Three-day dosing regimen; 115 mg (fosaprepitant dimeglumine) by I. infusion over 15 minutes starting 30 minutes before chemotherapy, with 12 mg dexamethasone P. 30 minutes before chemotherapy once daily and 8 mg ondansetron P. (a-prep-i-tant) Aprepitant inhibits, induces, and is metabolized by the CYP3A4 enzyme system; it also induces the CYP2C9 system.

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